Design of a vascularized synthetic poly(ethylene glycol) macroencapsulation device for islet transplantation.

ABSTRACT: The use of immunoisolating macrodevices in islet transplantation confers the benefit of safety and translatability by containing transplanted cells within a single retrievable device. To date, there has been limited development and characterization of synthetic poly(ethylene glycol) (PEG)-based hydrogel macrodevices for islet encapsulation and transplantation. Herein, we describe a two-component synthetic PEG hydrogel macrodevice system, designed for islet delivery to an extrahepatic islet transplant site, consisting of a hydrogel core cross-linked with a non-degradable PEG dithiol and a vasculogenic outer layer cross-linked with a proteolytically sensitive peptide to promote degradation and enhance localized vascularization. Synthetic PEG macrodevices exhibited equivalent passive molecula

SUBMITTER: Weaver JD 

PROVIDER: S-EPMC5967258 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature