Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain.

ABSTRACT: The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such as the 99^th percentile. A total of 4587 individuals enrolled in a prospective longitudinal study were used to develop a model for adjustment of cTn. cTnI levels correlated with age and estimated glomerular filtration rate (eGFR) in males/females with r_age = 0.436/0.518 and with r_eGFR = -0.142/-0.207. For adjustment, these variables served as covariates in a linear regression model with cTnI as dependent variable. This adjustment model was then a

SUBMITTER: Boeckel JN 

PROVIDER: S-EPMC5967336 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature