Whole-Brain Calcium Imaging Reveals an Intrinsic Functional Network in Drosophila.

ABSTRACT: A long-standing goal of neuroscience has been to understand how computations are implemented across large-scale brain networks. By correlating spontaneous activity during "resting states" [1], studies of intrinsic brain networks in humans have demonstrated a correspondence with task-related activation patterns [2], relationships to behavior [3], and alterations in processes such as aging [4] and brain disorders [5], highlighting the importance of resting-state measurements for understanding brain function. Here, we develop methods to measure intrinsic functional connectivity in Drosophila, a powerful model for the study of neural computation. Recent studies using calcium imaging have measured neural activity at high spatial and temporal resolution in zebrafish, Drosophila larvae, and worms

SUBMITTER: Mann K 

PROVIDER: S-EPMC5967399 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature