Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes.

ABSTRACT: Dinuclear platinum(II) complexes, [{Pt(en)Cl}₂(μ-qx)]Cl₂·2H₂O (1), [{Pt(en)Cl}₂(μ-qz)](ClO₄)₂ (2), and [{Pt(en)Cl}₂(μ-phtz)]Cl₂·4H₂O (3), were synthesized and characterized by different spectroscopic techniques. The crystal structure of 1 was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of 1-3. The chlorido Pt(II) complexes 1-3 were converted into the corresponding aqua species 1a-3a, and their reactions with an equimolar amount of Ac-L-Met-Gly and Ac-L-His-Gly dipeptides were studied by ¹H NMR spectroscopy in the pH range 2.0

SUBMITTER: Rajkovic S 

PROVIDER: S-EPMC5967607 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature