Neurocognitive and Educational Outcomes in Children and Adolescents with CKD: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background and objectives

Poor cognition can affect educational attainment, but the extent of neurocognitive impairment in children with CKD is not well understood. This systematic review assessed global and domain-specific cognition and academic skills in children with CKD and whether these outcomes varied with CKD stage.

Design, setting, participants, & measurements

Electronic databases were searched for observational studies of children with CKD ages 21 years old or younger that assessed neurocognitive or educational outcomes. Risk of bias was assessed using a modified Newcastle-Ottawa scale. We used random effects models and expressed the estimates as mean differences with 95% confidence intervals stratified by CKD stage.

Results

Thirty-four studies (25 cross-sect

SUBMITTER: Chen K 

PROVIDER: S-EPMC5967677 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature