Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

ABSTRACT: The global incidence of drug-resistant Gram-negative bacillary infections has been increasing, and there is a dire need to develop novel strategies to overcome this problem. Intrinsic resistance in Gram-negative bacteria, such as their protective outer membrane and constitutively overexpressed efflux pumps, is a major survival weapon that renders them refractory to current antibiotics. Several potential avenues to overcome this problem have been at the heart of antibiotic drug discovery in the past few decades. We review some of these strategies, with emphasis on antibiotic hybrids either as stand-alone antibacterial agents or as adjuvants that potentiate a primary antibiotic in Gram-negative bacteria. Antibiotic hybrid is defined in this review as a synthetic construct of two or more phar

SUBMITTER: Domalaon R 

PROVIDER: S-EPMC5967690 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature