Ancestry-specific recent effective population size in the Americas.

ABSTRACT: Populations change in size over time due to factors such as population growth, migration, bottleneck events, natural disasters, and disease. The historical effective size of a population affects the power and resolution of genetic association studies. For admixed populations, it is not only the overall effective population size that is of interest, but also the effective sizes of the component ancestral populations. We use identity by descent and local ancestry inferred from genome-wide genetic data to estimate overall and ancestry-specific effective population size during the past hundred generations for nine admixed American populations from the Hispanic Community Health Study/Study of Latinos, and for African-American and European-American populations from two US cities. In these popula

SUBMITTER: Browning SR 

PROVIDER: S-EPMC5967706 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature