The characteristic patterns of neuronal avalanches in mice under anesthesia and at rest: An investigation using constrained artificial neural networks.

ABSTRACT: Local perturbations within complex dynamical systems can trigger cascade-like events that spread across significant portions of the system. Cascades of this type have been observed across a broad range of scales in the brain. Studies of these cascades, known as neuronal avalanches, usually report the statistics of large numbers of avalanches, without probing the characteristic patterns produced by the avalanches themselves. This is partly due to limitations in the extent or spatiotemporal resolution of commonly used neuroimaging techniques. In this study, we overcome these limitations by using optical voltage (genetically encoded voltage indicators) imaging. This allows us to record cortical activity in vivo across an entire cortical hemisphere, at both high spatial (~30um) and temporal (~

SUBMITTER: Fagerholm ED 

PROVIDER: S-EPMC5967741 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature