Persistent high plasma levels of sCD163 and sCD14 in adult patients with measles virus infection.

ABSTRACT:

Background and aims

Measles is an infectious disease that represents a serious public health problem worldwide, being associated with increased susceptibility to secondary infections, especially in the respiratory and gastrointestinal tracts. The aim of this study was to evaluate sCD163 and sCD14 levels in measles virus (MV) infected patients, as markers of immune activation, in order to better understand their role in the pathogenesis of the disease. TNF-α plasma levels were also evaluated.

Methods

sCD163, sCD14 and TNF-α were measured by ELISA in plasma samples of 27 MV infected patients and 27 healthy donors (HD) included as controls.

Results

At the time of hospital admission, sCD163 and sCD14 levels were significantly higher in MV infected patients than in HD, whi

SUBMITTER: Mascia C 

PROVIDER: S-EPMC5967820 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature