Xenotransplantation of adult hippocampal neural progenitors into the developing zebrafish for assessment of stem cell plasticity.

ABSTRACT: Adult stem cells are considered multipotent, restricted to differentiate into a few tissue-specific cell types. With the advent of technologies which can dedifferentiate and transdifferentiate cell types, assumptions about the process of cell fate determination must be reconsidered, including the role of extrinsic versus intrinsic factors. To determine the plasticity of adult neural progenitors, rat hippocampal progenitor cells were xenotransplanted into embryonic zebrafish. These animals allow for easy detection of transplanted cells due to their external development and transparency at early stages. Adult neural progenitors were observed throughout the zebrafish for the duration of the experiment (at least five days post-transplantation). While the majority of transplanted cells were obs

SUBMITTER: Sandquist EJ 

PROVIDER: S-EPMC5967829 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature