Radiation-Induced Long Noncoding RNAs in a Mouse Model after Whole-Body Irradiation.

ABSTRACT: Long noncoding RNAs (lncRNAs) are emerging as key molecules in regulating many biological processes and have been implicated in development and disease pathogenesis. Biomarkers of cancer and normal tissue response to treatment are of great interest in precision medicine, as well as in public health and medical management, such as for assessment of radiation injury after an accidental or intentional exposure. Circulating and functional RNAs, including microRNAs (miRNAs) and lncRNAs, in whole blood and other body fluids are potential valuable candidates as biomarkers. Early prediction of possible acute, intermediate and delayed effects of radiation exposure enables timely therapeutic interventions. To address whether long noncoding RNAs (lncRNAs) could serve as biomarkers for radiation biodo

SUBMITTER: Aryankalayil MJ 

PROVIDER: S-EPMC5967844 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature