Improving risk estimates for metabolically healthy obesity and mortality using a refined healthy reference group.

ABSTRACT:

Objective

We aimed to re-examine mortality risk estimates for metabolically healthy obesity by using a 'stable' healthy non-obese referent group.

Design

Prospective cohort study.

Methods

Participants were 5427 men and women (aged 65.9 ± 9.4 years, 45.9% men) from the English Longitudinal Study of Ageing. Obesity was defined as body mass index ≥30 kg/m² (vs non-obese as below this threshold). Based on blood pressure, HDL cholesterol, triglycerides, glycated hemoglobin and C-reactive protein, participants were classified as 'healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (≥2 metabolic abnormalities).

Results

Totally, 671 deaths were observed over an average follow-up of 8 years. When defining the referent group based on 1 clinical assessment, t

SUBMITTER: Hamer M 

PROVIDER: S-EPMC5967883 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature