Beyond degree and betweenness centrality: Alternative topological measures to predict viral targets.

ABSTRACT: The availability of large-scale screens of host-virus interaction interfaces enabled the topological analysis of viral protein targets of the host. In particular, host proteins that bind viral proteins are generally hubs and proteins with high betweenness centrality. Recently, other topological measures were introduced that a virus may tap to infect a host cell. Utilizing experimentally determined sets of human protein targets from Herpes, Hepatitis, HIV and Influenza, we pooled molecular interactions between proteins from different pathway databases. Apart from a protein's degree and betweenness centrality, we considered a protein's pathway participation, ability to topologically control a network and protein PageRank index. In particular, we found that proteins with increasing values of

SUBMITTER: Devkota P 

PROVIDER: S-EPMC5967884 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature