The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile.

ABSTRACT:

Introduction

Several polymorphisms have been associated with obesity and type 2 diabetes in different populations.

Objective

To investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D.

Methods

The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects.

Results

The frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of th

SUBMITTER: Angel B 

PROVIDER: S-EPMC5968031 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature