Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of <i>Artemisia annua</i>.

ABSTRACT: Chemical derivatives of artemisinin, a sesquiterpene lactone produced by Artemisia annua, are the active ingredient in the most effective treatment for malaria. Comprehensive phytochemical analysis of two contrasting chemotypes of A. annua resulted in the characterization of over 80 natural products by NMR, more than 20 of which are novel and described here for the first time. Analysis of high- and low-artemisinin producing (HAP and LAP) chemotypes of A. annua confirmed the latter to have a low level of DBR2 (artemisinic aldehyde Δ¹¹⁽¹³⁾ reductase) gene expression. Here we show that the LAP chemotype accumulates high levels of artemisinic acid, arteannuin B, epi-deoxyarteannuin B and other amorpha-4,11-diene derived sesquiterpenes which are uns

SUBMITTER: Czechowski T 

PROVIDER: S-EPMC5968107 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature