Lack of Association Between Shape and Volume of Subcortical Brain Structures and Restless Legs Syndrome.

ABSTRACT:

Objective

Previous studies on patients with restless legs syndrome (RLS) yielded inconclusive results in the magnetic resonance imaging (MRI)-based analyses of alterations of subcortical structures in the brain. The aim of this study was to compare volumes as well as shapes of subcortical structures and the hippocampus between RLS cases and controls. Additionally, the associations between the genetic risks for RLS and subcortical volumes were investigated.

Methods

We compared volumetric as well as shape differences assessed by 3 T MRI in the caudate nucleus, hippocampus, globus pallidus, putamen, and thalamus in 39 RLS cases versus 117 controls, nested within a population-based sample. In a subsample, we explored associations between known genetic risk markers for RLS and th

SUBMITTER: Hermesdorf M 

PROVIDER: S-EPMC5968110 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature