Development of Structural Covariance From Childhood to Adolescence: A Longitudinal Study in 22q11.2DS.

ABSTRACT: Background: Schizophrenia is currently considered a neurodevelopmental disorder of connectivity. Still few studies have investigated how brain networks develop in children and adolescents who are at risk for developing psychosis. 22q11.2 Deletion Syndrome (22q11DS) offers a unique opportunity to investigate the pathogenesis of schizophrenia from a neurodevelopmental perspective. Structural covariance (SC) is a powerful approach to explore morphometric relations between brain regions that can furthermore detect biomarkers of psychosis, both in 22q11DS and in the general population. Methods: Here we implement a state-of-the-art sliding-window approach to characterize maturation of SC network architecture in a large longitudinal cohort of patients with 22q11DS (110 with 221 visi

SUBMITTER: Sandini C 

PROVIDER: S-EPMC5968113 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature