Dynamic Calcium Release From Endoplasmic Reticulum Mediated by Ryanodine Receptor 3 Is Crucial for Oligodendroglial Differentiation.

ABSTRACT: Increased intracellular Ca²⁺ in oligodendrocyte progenitor cells (OPCs) is important to initiate their differentiation, but the intracellular Ca²⁺ channel involved in this process remains unclear. As a Ca²⁺-induced Ca²⁺ release (CICR) channel that mediates endoplasmic reticulum (ER) Ca²⁺ release, the role of ryanodine receptors (RyRs) in oligodendroglial development is unexplored. In the present study, we observed that among the three mammalian isoforms, oligodendroglial lineage cells selectively expressed RyR3. Strong RyR3-positive signal was distributed all over the cytoplasm and processes in OPCs and/or immature OLs (imOLs), whereas it gradually decreased and was located mainly around the perinuclear region in mature oligodendrocyte

SUBMITTER: Li T 

PROVIDER: S-EPMC5968115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature