Neuronal Activation in the Periaqueductal Gray Matter Upon Electrical Stimulation of the Bladder.

ABSTRACT: Reflexes, that involve the spinobulbospinal pathway control both storage and voiding of urine. The periaqueductal gray matter (PAG), a pontine structure is part of the micturition pathway. Alteration in this pathway could lead to micturition disorders and urinary incontinence, such as the overactive bladder symptom complex (OABS). Although different therapeutic options exist for the management of OABS, these are either not effective in all patients. Part of the pathology of OABS is faulty sensory signaling about the filling status of the urinary bladder, which results in aberrant efferent signaling leading to overt detrusor contractions and the sensation of urgency and frequent voiding. In order to identify novel targets for therapy (i.e., structures in the central nervous system) and expl

SUBMITTER: Meriaux C 

PROVIDER: S-EPMC5968116 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature