Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern?

ABSTRACT: OBJECTIVE:To investigate the effect of the common fat mass and obesity-associated (FTO) gene polymorphism rs9939609 on body mass index (BMI) in one of the most obese populations worldwide. SUBJECTS AND METHODS:Genotypic data for FTO rs9939609 were available for 1,034 unrelated Kuwaiti adults obtained from Kuwait's Dasman Diabetes Institute and Kuwait University. The association between the FTO polymorphism with BMI as continuous and categorical (normal BMI [< 25] vs. overweight/obese [> 25]) variables was analyzed using both linear and logistic regression models, respectively, with the assumption of both dominant and additive genetic models performed using the SNPassoc package from R statistics. RESULTS:The A allele was associated with increased BMI (β = 1.21; 95% CI = 0.16-2.26; p = 0.023

SUBMITTER: Al-Serri A 

PROVIDER: S-EPMC5968256 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature