An assessment of public health surveillance of Zika virus infection and potentially associated outcomes in Latin America.

ABSTRACT:

Background

We evaluated whether outbreaks of Zika virus (ZIKV) infection, newborn microcephaly, and Guillain-Barré syndrome (GBS) in Latin America may be detected through current surveillance systems, and how cases detected through surveillance may increase health care burden.

Methods

We estimated the sensitivity and specificity of surveillance case definitions using published data. We assumed a 10% ZIKV infection risk during a non-outbreak period and hypothetical increases in risk during an outbreak period. We used sensitivity and specificity estimates to correct for non-differential misclassification, and calculated a misclassification-corrected relative risk comparing both periods. To identify the smallest hypothetical increase in risk resulting in a detectable outbreak w

SUBMITTER: Bautista LE 

PROVIDER: S-EPMC5968501 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature