Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota.

ABSTRACT:

Background

The early-life gut microbiota plays a critical role in host metabolism in later life. However, little is known about how the fatty acid profile of the maternal diet during gestation and lactation influences the development of the offspring gut microbiota and subsequent metabolic health outcomes.

Results

Here, using a unique transgenic model, we report that maternal endogenous n-3 polyunsaturated fatty acid (PUFA) production during gestation or lactation significantly reduces weight gain and markers of metabolic disruption in male murine offspring fed a high-fat diet. However, maternal fatty acid status appeared to have no significant effect on weight gain in female offspring. The metabolic phenotypes in male offspring appeared to be mediated by comprehensive restr

SUBMITTER: Robertson RC 

PROVIDER: S-EPMC5968592 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature