Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures.

ABSTRACT: BACKGROUND:Pyrethroids, such as bifenthrin (BF), are among the most widely used class of insecticides that pose serious risks to human and wildlife health. Pyrethroids are proposed to affect astrocytic functions and to cause neuron injury in the central nervous system (CNS). Microglia are key cells involved in innate immune responses in the CNS, and microglia activation has been linked to inflammation and neurotoxicity. However, little information is known about the effects of BF-induced toxicity in primary microglial cells as well as in organotypic hippocampal slice cultures (OHSCs). METHODS:Oxidative stress and inflammatory responses induced by BF were evaluated in primary microglial cells and OHSCs incubated with different concentrations of BF (1-20 μM) for 4 and 24 h. mRNA and protein

SUBMITTER: Gargouri B 

PROVIDER: S-EPMC5968622 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature