REST, not REST4, is a risk factor associated with radiotherapy plus chemotherapy efficacy in glioma.

ABSTRACT:

Background/aim

Repressor element silencing transcription factor (REST) is a transcription repressor, expressed in several malignancies. This study aims to evaluate the prognostic values of REST and its splicing variant REST4 in glioma, and investigate the potential correlation between REST and REST4.

Methods

REST and REST4 expression values were evaluated by qRT-PCR in 89 patients with gliomas and 10 with normal brain tissues.

Results

Upregulation of REST was related to higher World Health Organization (WHO) grade, larger tumor size, higher ki67, and higher p53 positive rate. After radiotherapy+temozolomide (RT+TMZ) treatment, low REST expression patients could get better therapeutic efficacy (P=0.0

SUBMITTER: Li C 

PROVIDER: S-EPMC5968789 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature