Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults.

ABSTRACT:

Background and objectives

Cognitive function worsens as kidney function declines, but mechanisms contributing to this association are not completely understood. Metabolic acidosis, a common complication of CKD, leads to neural networks overexcitation and is involved in cerebral autoregulation. We aimed to evaluate the association between serum bicarbonate concentration as a measure of metabolic acidosis, and cognitive function in hypertensive adults with and without CKD.

Design, setting, participants, & measurements

Five cognitive summary scores were measured (global cognitive function, executive function, memory, attention/concentration, and language) in 2853 participants in the Systolic BP Intervention Trial (SPRINT). Multivariable linear regression models adjusted for dem

SUBMITTER: Dobre M 

PROVIDER: S-EPMC5968905 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature