Systematic review of outcome measures following chemoradiotherapy for the treatment of anal cancer (CORMAC).

ABSTRACT:

Aim

Six Phase III randomized trials have determined the effectiveness of chemoradiotherapy as primary treatment for anal squamous cell carcinoma (ASCC), but outcomes reported in these trials varied widely, hindering evidence synthesis. To improve reporting in all future trials, we aim to develop a core outcomes set (COS). As the first stage of COS development, we undertook a systematic review to summarize the outcomes reported in studies evaluating chemoradiotherapy for ASCC.

Method

Systematic literature searches identified studies evaluating radiotherapy or chemoradiotherapy for ASCC. Outcomes and accompanying definitions were extracted verbatim and categorized into domains.

Results

From 5170 abstracts, we identified 95 eligible studies, reporting 1192 outcomes and 5

SUBMITTER: Fish R 

PROVIDER: S-EPMC5969105 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature