The impact of B1+ correction on MP2RAGE cortical T₁ and apparent cortical thickness at 7T.

ABSTRACT: Determination of cortical thickness using MRI has often been criticized due to the presence of various error sources. Specifically, anatomical MRI relying on T₁ contrast may be unreliable due to spatially variable image contrast between gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). Especially at ultra-high field (≥ 7T) MRI, transmit and receive B₁ -related image inhomogeneities can hamper correct classification of tissue types. In the current paper, we demonstrate that residual B1+ (transmit) inhomogeneities in the T₁ -weighted and quantitative T₁ images using the MP2RAGE sequence at 7T lead to biases in cortical thickness measurements. As expected, post-hoc correction for the spatially varying B1+ profile reduced the apparen

SUBMITTER: Haast RAM 

PROVIDER: S-EPMC5969159 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature