Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study.

ABSTRACT: To understand the heterogeneity of functional connectivity results reported in the literature, we analyzed the separate effects of grey and white matter damage on functional connectivity and networks in multiple sclerosis. For this, we employed a biophysical thalamo-cortical model consisting of interconnected cortical and thalamic neuronal populations, informed and amended by empirical diffusion MRI tractography data, to simulate functional data that mimic neurophysiological signals. Grey matter degeneration was simulated by decreasing within population connections and white matter degeneration by lowering between population connections, based on lesion predilection sites in multiple sclerosis. For all simulations, functional connectivity and functional network organization are quantified

SUBMITTER: Tewarie P 

PROVIDER: S-EPMC5969233 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature