Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow.

ABSTRACT:

Aims

Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric surgery on intestinal fatty acid (FA) uptake and blood flow.

Materials and methods

We recruited 27 morbidly obese subjects, of whom 10 had type 2 diabetes and 15 were healthy age-matched controls. Intestinal blood flow and fatty acid uptake from circulation were measured during fasting state using positron emission tomography (PET). Obese subjects were re-studied 6 months after bariatric surgery. The mucosal location of intestinal FA retention was verified in insulin resistant mice with autoradiography.

Results

Compared to lean subjects, morbidly obes

SUBMITTER: Koffert J 

PROVIDER: S-EPMC5969261 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature