Lipoprotein modifications by gingipains of Porphyromonas gingivalis.

ABSTRACT:

Background and objective

Several studies have shown an association between periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause of CVD, and a key event in the development of atherosclerosis is accumulation of lipoproteins within the arterial wall. Bacteria are the primary etiologic agents in periodontitis and Porphyromonas gingivalis is the major pathogen in the disease. Several studies support a role of modified low-density lipoprotein (LDL) in atherogenesis; however, the pathogenic stimuli that induce the changes and the mechanisms by which this occur are unknown. This study aims to identify alterations in plasma lipoproteins induced by the periodontopathic species of bacterium, P. gingivalis, in vitro.

Material and methods

Plasma lipoproteins

SUBMITTER: Lonn J 

PROVIDER: S-EPMC5969291 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature