Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders.

ABSTRACT:

Introduction

Vulnerability to psychiatric manifestations is achieved by the influence of genetic and environment including stress and cannabis consumption. Here, we used a psychosocial stress model based on resident-intruder confrontations to study the brain corticostriatal-function, since deregulation of corticostriatal circuitries has been reported in many psychiatric disorders. CB₁ receptors are widely expressed in the central nervous system and particularly, in both cortex and striatum brain structures.

Aims and methods

The investigation presented here is addressed to assess the impact of repeated stress following acute cannabinoid exposure on behavior and corticostriatal brain physiology by assessing mice behavior, the concentration of endocannabinoid and end

SUBMITTER: Tomas-Roig J 

PROVIDER: S-EPMC5969305 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature