Occupational exposure to pesticides is associated with differential DNA methylation.

ABSTRACT:

Objectives

Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational exposure to pesticides and genome-wide DNA methylation sites.

Methods

1561 subjects of LifeLines were included with either no (n=1392), low (n=108) or high (n=61) exposure to any type of pesticides (estimated based on current or last held job). Blood DNA methylation levels were measured using Illumina 450K arrays. Associations between pesticide exposure and 420 938 methylation sites (CpGs) were assessed using robust linear regression adjusted for

SUBMITTER: van der Plaat DA 

PROVIDER: S-EPMC5969365 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature