Attributable Risk and Time Course of Colistin-Associated Acute Kidney Injury.

ABSTRACT:

Background and objectives

Despite colistin's longstanding reported association with nephrotoxicity, the attributable risk and timing of toxicity onset are still unknown. Whether substantial toxicity occurs during the initial 72 hours of exposure has important implications for early treatment decisions. The objective of this study was to compare colistin-exposed patients with a matched control group given other broad spectrum antibiotics.

Design, setting, participants, & measurements

We conducted a retrospective cohort study in patients treated for multidrug-resistant Pseudomonas, Klebsiella, or Acinetobacter spp. Colistin-exposed patients were matched to unexposed controls using propensity scores. AKI was defined according to the Kidney Disease Improving

SUBMITTER: Miano TA 

PROVIDER: S-EPMC5969457 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature