Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients.

ABSTRACT:

Background and objectives

Dysregulated mineral metabolism is a common and potentially maladaptive feature of critical illness, especially in patients with AKI, but its association with death has not been comprehensively investigated. We sought to determine whether elevated plasma levels of the osteocyte-derived, vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23), are prospectively associated with death in critically ill patients with AKI requiring RRT, and in a general cohort of critically ill patients with and without AKI.

Design, setting, participants, & measurements

We measured plasma FGF23 and other mineral metabolite levels in two cohorts of critically ill patients (n=1527). We included 817 patients with AKI requiring RRT who enrolled in the ARF Tr

SUBMITTER: Leaf DE 

PROVIDER: S-EPMC5969465 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature