Time-Centered Approach to Understanding Risk Factors for the Progression of CKD.

ABSTRACT: BACKGROUND AND OBJECTIVES:Traditional approaches to modeling risk of CKD progression do not provide estimates of the time it takes for disease progression to occur, which could be useful in guiding therapeutic interactions between patients and providers. Our objective was to estimate median time spent in each of CKD stages 3a-5 and how the time differs according to risk factors associated with progression of disease. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:We included 3682 participants of the Chronic Renal Insufficiency Cohort in mixed models to estimate person-specific trajectories of function, and used these trajectories to estimate time spent in each CKD stage. RESULTS:During 9.5 years of median follow-up, participants spent longer in earlier rather than later CKD stages, ranging

SUBMITTER: Ku E 

PROVIDER: S-EPMC5969480 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature