Hydroxychloroquine Use and Risk of CKD in Patients with Rheumatoid Arthritis.

ABSTRACT: BACKGROUND AND OBJECTIVES:Hydroxychloroquine is widely used in patients with rheumatoid arthritis. However, large-scale studies examining the long-term effects of hydroxychloroquine on the development of kidney disease in patients with rheumatoid arthritis are lacking. We aimed to assess the long-term association of hydroxychloroquine use with the risk of developing CKD in this population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:We conducted an observational cohort study for patients with newly diagnosed rheumatoid arthritis who were enrolled prospectively in Taiwan's National Health Insurance Research Database between January 1, 2000 and December 31, 2013. We used multivariable Cox proportional hazard regression to analyze the association of hydroxychloroquine use with incident CKD.

SUBMITTER: Wu CL 

PROVIDER: S-EPMC5969483 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature