Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.

ABSTRACT: Platelets are blood cells with numerous crucial pathophysiological roles in hemostasis, cardiovascular thrombotic events and cancer metastasis. Platelet activation requires the engagement of intracellular signalling pathways that involve protein-protein interactions (PPIs). A better understanding of these pathways is therefore crucial for the development of selective anti-platelet drugs. New strategies for studying PPIs in human platelets are required to overcome limitations associated with conventional platelet research methods. For example, small molecule inhibitors can lack selectivity and are often difficult to design and synthesise. Additionally, development of transgenic animal models is costly and time-consuming and conventional recombinant techniques are ineffective due to the lack

SUBMITTER: Iegre J 

PROVIDER: S-EPMC5969508 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature