Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection.

ABSTRACT: Photoacoustic microscopy (PAM) is an attractive imaging tool complementary to established optical microscopic modalities by providing additional molecular specificities through imaging optical absorption contrast. While the development of optical resolution photoacoustic microscopy (ORPAM) offers high lateral resolution, the acoustically-determined axial resolution is limited due to the constraint in ultrasonic detection bandwidth. ORPAM with isometric spatial resolution along both axial and lateral direction is yet to be developed. Although recently developed sophisticated optical illumination and reconstruction methods offer improved axial resolution in ORPAM, the image acquisition procedures are rather complicated, limiting their capabilities for high-speed imaging and being easily inte

SUBMITTER: Dong B 

PROVIDER: S-EPMC5969522 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature