Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.

ABSTRACT: Infectious disease has shaped the natural genetic diversity of humans throughout the world. A new approach to capture positive selection driven by pathogens would provide information regarding pathogen exposure in distinct human populations and the constantly evolving arms race between host and disease-causing agents. We created a human pathogen interaction database and used the integrated haplotype score (iHS) to detect recent positive selection in genes that interact with proteins from 26 different pathogens. We used the Human Genome Diversity Panel to identify specific populations harboring pathogen-interacting genes that have undergone positive selection. We found that human genes that interact with 9 pathogen species show evidence of recent positive selection. These pathogens are Yers

SUBMITTER: Corona E 

PROVIDER: S-EPMC5969750 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature