A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis.

ABSTRACT: There are no defined correlates of protection for any intracellular pathogen, including the bacterium Francisella tularensis, which causes tularemia. Evaluating vaccine efficacy against sporadic diseases like tularemia using field trials is problematic, and therefore alternative strategies to test vaccine candidates like the Francisella Live Vaccine Strain (LVS), such as testing in animals and applying correlate measurements, are needed. Recently, we described a promising correlate strategy that predicted the degree of vaccine-induced protection in mice given parenteral challenges, primarily when using an attenuated Francisella strain. Here, we demonstrate that using peripheral blood lymphocytes (PBLs) in this approach predicts LVS-mediated protection against respiratory challenge of Fisch

SUBMITTER: De Pascalis R 

PROVIDER: S-EPMC5969757 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature