Hormone therapy and urine protein excretion: a multiracial cohort study, systematic review, and meta-analysis.

ABSTRACT:

Objective

Experimental models suggest estrogen has a renoprotective effect, but human studies show variable results. Our objective was to study the association of hormone therapy (HT) and albuminuria in postmenopausal women and to synthesize the results with outcomes from prior studies.

Methods

We analyzed data from postmenopausal women who participated in the second study visit (2000-2004) of the Genetic Epidemiology Network of Arteriopathy (GENOA) study. The exposure was self-reported HT use and the outcome was albuminuria (urine albumin-to-creatinine ratio >25 mg/g creatinine). We also conducted a systematic review and meta-analysis on the association of HT and urine protein in postmenopausal women. Continuous and dichotomous measures of protein excretion were converted t

SUBMITTER: Kattah AG 

PROVIDER: S-EPMC5970005 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature