Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels.

ABSTRACT:

Background

Triclosan, an antimicrobial agent used in some consumer products, reduces endogenous thyroid hormone concentrations in rodents. Despite ubiquitous triclosan exposure and the importance of thyroid hormones for normal fetal development, few human studies have examined the impact of triclosan exposure on maternal, neonatal, or child thyroid hormones.

Methods

In the HOME Study, a prospective cohort from Cincinnati, OH, we measured urinary triclosan concentrations up to three times in pregnant women between 16weeks and delivery, and up to three times in children between age 1-3years. We quantified serum concentrations of thyroid stimulating hormone and total and free thyroxine and triiodothyronine in mothers at 16-weeks gestation (n=202), neonates at delivery (n=274),

SUBMITTER: Braun JM 

PROVIDER: S-EPMC5970023 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature