The Rbm38-p63 feedback loop is critical for tumor suppression and longevity.

ABSTRACT: The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop. To investigate the biological significance of the Rbm38-p63 loop in vivo, a cohort of WT, Rbm38^-/-, TAp63^+/-, and Rbm38^-/-;TAp63^+/- mice were generated and monitored throughout their lifespan. While mice deficient in Rbm38 or TAp63 alone died mostly from spontaneous tumors, compound Rbm38^-/-;TAp63^+/- mice had an extended lifespan along with reduced tumor incidence. We also found that loss-of-Rbm38 markedly decreased the percentage of liver steatosis in TAp63^+/- mice. Moreover, we found that Rbm38 deficiency extends the lifespan of

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC5970038 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature