Progenitor Cells and Clinical Outcomes in Patients With Acute Coronary Syndromes.

ABSTRACT:

Rationale

Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown in acute coronary syndrome (ACS).

Objective

We aimed to investigate the number of CPCs in ACS compared with those with stable coronary artery disease (CAD), relationship between bone marrow PCs and CPCs, and whether CPC counts predict mortality in patients with ACS.

Methods and results

In 2028 patients, 346 had unstable angina, 183 had an acute myocardial infarction (AMI), and the remaining 1499 patients had stable CAD. Patients with ACS were followed for the primary end point of all-cause death. CPCs were enumerated by flow cytometry as mononuclear cells expressing a combination of CD34+, CD133+, vascular endothelial growth factor receptor

SUBMITTER: Samman Tahhan A 

PROVIDER: S-EPMC5970041 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature