Effects of Low-level Brodifacoum Exposure on the Feline Immune Response.

ABSTRACT: Anticoagulant rodenticides have been implicated as a potential inciting factor in the development of mange in wild felids, but a causative association between anticoagulant rodenticide exposure and immune suppression has not been established. Specific-pathogen-free domestic cats were exposed to brodifacoum over a 6-week period to determine whether chronic, low-level exposure altered the feline immune response. Cats were vaccinated with irrelevant antigens at different points during the course of the experiment to assess recall and direct immune responses. Measures of immune response included delayed-type hypersensitivity tests and cell proliferation assays. IgE and antigen-specific antibodies were quantified via ELISA assays, and cytokine induction following exposure to vaccine antigens wa

SUBMITTER: Kopanke JH 

PROVIDER: S-EPMC5970145 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature