Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.

ABSTRACT:

Background

Neuroinflammation is thought to play an important role in the pathogenesis of ICU-acquired delirium, but the association between inflammatory and brain-specific proteins and ICU delirium is poor. We investigated whether or not serial determinations of markers may improve this association.

Methods

Critically ill patients with a high risk of ICU delirium and with an ICU length of stay of at least 6 days were included in the study. Blood was drawn on days 1, 2, 4 and 6 after ICU admission and analyzed for different markers of inflammation and several brain proteins. Differences in courses over time prior to and following the onset of delirium and absolute differences over time were analyzed in patients with and without delirium using repeated measurement analysis of

SUBMITTER: Simons KS 

PROVIDER: S-EPMC5970442 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature