Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms.

ABSTRACT: BACKGROUND:Over the past 30 years, evidence has been accumulating for an immunological component to schizophrenia etiology, including genetic links to the major histocompatibility complex, microglia activation, and dysregulated cytokine profiles. However, the degree of similarity in cytokine profiles for schizophrenia and bipolar disorder, as well as the relationship between cytokine levels and brain structure, is less well understood. METHODS:To address this, we recruited 69 first-episode schizophrenia-spectrum patients, 16 first-episode bipolar patients with psychotic features, and 53 healthy controls, from the UC Davis EDAPT clinic. Blood plasma was collected and analyzed for all participants with a subset of participants that also underwent structural MRI on a 1.5T GE scanner. RESULTS:

SUBMITTER: Lesh TA 

PROVIDER: S-EPMC5970482 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature