Analysis of the PvuII and XbaI polymorphisms in the estrogen receptor alpha gene in girls with central precocious puberty: a pilot study.

ABSTRACT:

Background

Precocious puberty (PP) is defined as premature pubertal development. Its consequences surpass the physical evidence of sexual maturity with the premature epiphyseal closure of the long bones and the reduction of adult stature by varied degrees. Central PP is characteristically dependent on GnRH and most of its causes are not completely known. Altered estrogen action is also believed to be involved in the genesis of PP. In fact, estrogen receptor alpha (Rea) gene polymorphisms may be associated with early age at menarche. The objective of this study was to investigate the relationship between Reα gene polymorphisms (PvuII and XbaI) and the occurrence of central PP.

Methods

A total of 73 girls with central PP and 101 girls with normal pubertal maturation were evalu

SUBMITTER: Soares-Jr JM 

PROVIDER: S-EPMC5970514 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature