A role for the cytoskeleton-associated protein palladin in neurite outgrowth.

ABSTRACT: The outgrowth of neurites is a critical step in neuronal maturation, and it is well established that the actin cytoskeleton is involved in this process. Investigators from our laboratory recently described a novel protein named palladin, which has been shown to play an essential role in organizing the actin cytoskeleton in cultured fibroblasts. We investigated the expression of palladin in the developing rat brain by Western blot and found that the E18 brain contained a unique variant of palladin that is significantly smaller (approximately 85 kDa) than the common form found in other developing tissues (90-92 kDa). Because the expression of a tissue-specific isoform suggests the possibility of a cell type-specific function, we investigated the localization and function of palladin in cultu

SUBMITTER: Boukhelifa M 

PROVIDER: S-EPMC59707 | biostudies-literature | 2001 Sep

REPOSITORIES: biostudies-literature