Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study.

ABSTRACT:

Background

Mosaic loss of chromosome Y (mLOY) can occur in a fraction of cells as men age, which is potentially linked to increased mortality risk. Smoking is related to mLOY; however, the contribution of air pollution is unclear.

Objective

We investigated whether exposure to outdoor air pollution, age, and smoking were associated with mLOY.

Methods

We analyzed baseline (1989-1993) blood samples from 933 men ≥65 years of age from the prospective Cardiovascular Health Study. Particulate matter ≤10 μm (PM₁₀), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone data were obtained from the U.S. EPA Aerometric Information Retrieval System for the year prior to baseline. Inverse-distance weighted air monitor data were used to estimate each participants'

SUBMITTER: Wong JYY 

PROVIDER: S-EPMC5971001 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature